Movement Disorders

Huntington Disease

Autosomal Dominant

Trinucleotide repeat on chromosome 4

Brilliant organizer in PPP

B–>C–>D

Behavioral –> Chorea –> Dementia

Dx: CT Scan shows atrophy of cerebral and caudate nucleus

Tx: No cure

Parkinson Disease

DEPLETION OF DOPAMINE 

Loss of cells in the SUBSTANTIA NIGRA

Resting tremor

Flat affect

Associated seborrhea dermatitis common

Essential Tremor

Autosomal Dominant (look for familiar history in questions!!)

Tremor worse with movement and stress

ALCOHOL RELIEVES TREMOR

Tx: Propanolol 

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